Ketamine Infusion for Depression

In most depressive disorders, the dopamine pathways in the brain are inhibited or not properly functional. Ketamine in low doses has been implicated to aid in the creation of dopamine and other neurotransmitters that control depression in the brain and therefore, are shown to reduce symptoms of depression following infusions. Patients with bipolar depression and major depressive disorders are best suited for treatment for ketamine infusion therapy due to the relationship between these disorders and dopamine levels in the brain. Some types of depression disorders that respond well to ketamine infusion treatment are outlined below:
  • Bipolar Depression
  • Major Depressive Disorder
  • Persistent Depressive Disorder
Citations

  • Maltbie, E. A., Kaundinya, G. S., & Howell, L. L. (2017). Ketamine and pharmacological imaging: use of functional magnetic resonance imaging to evaluate mechanisms of action. Behavioural pharmacology, 28(8), 610–622. https://doi.org/10.1097/FBP.0000000000000354
  • McCloud TL, Caddy C, Jochim J, et al. Ketamine and other glutamate receptor modulators for depression in bipolar disorder in adults. Cochrane Database Syst Rev. 2015;(9):CD011611. Published 2015 Sep 29. doi:10.1002/14651858.CD011611.pub2

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